cdp-323 (Celltech Inc)
90
Structured Review
Celltech Inc
cdp-323
Cdp 323, supplied by Celltech Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/cdp-323/cdp+323/pm17631252-119-1-14
Average 90 stars, based on 1 article reviews
Cdp 323, supplied by Celltech Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/cdp-323/cdp+323/pm17631252-119-1-14
Average 90 stars, based on 1 article reviews
cdp-323 - by Bioz Stars,
2026-09
90/100 stars
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other:Article Title: Alpha4-integrin antagonism--an effective approach for the treatment of inflammatory diseases? Article Snippet: Inhibition of leucocyte trafficking by antagonism of the alpha4 (a4)-integrin has now been validated as a therapeutic approach for the treatment of inflammatory diseases such as multiple sclerosis (MS) and inflammatory bowel disease (IBD).. This validation has been overshadowed by three incidences of progressive multifocal leucoencaphalopathy (PML) in patients receiving natalizumab (Tysabri), a therapeutic monoclonal IgG antibody directed against a4-integrins.. This led to the initial removal of natalizumab from the market. Article Title: Therapeutic targeting of leukocyte trafficking across the blood-brain barrier. Article Snippet: The central nervous system (CNS) has long been regarded as an immune privileged organ implying that the immune system avoids the CNS not to disturb its homeostasis, which is critical for proper function of neurons.. Meanwhile, it is accepted that immune cells do in fact gain access to the CNS and that immune responses are mounted within this tissue.. However, the unique CNS microenvironment strictly controls these immune reactions starting with tightly regulating immune cell entry into the tissue. |
